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rted¡¡to¡¡macerations¡¡and¡¡injections¡¡for¡¡the¡¡study¡¡of¡¡certain¡¡complicated¡¡structures¡£¡¡But¡¡while¡¡the¡¡fruit¡¡of¡¡his¡¡pen¡¡and¡¡pencil¡¡were¡¡lost¡¡for¡¡more¡¡than¡¡a¡¡century¡¡after¡¡his¡¡death£»¡¡the¡¡effects¡¡of¡¡his¡¡teachings¡¡were¡¡not£»¡¡and¡¡his¡¡two¡¡pupils£»¡¡Fallopius¡¡and¡¡Columbus£»¡¡are¡¡almost¡¡as¡¡well¡¡known¡¡to¡day¡¡as¡¡their¡¡illustrious¡¡teacher¡£¡¡Columbus¡¡£¨1490¡1559£©¡¡did¡¡much¡¡in¡¡correcting¡¡the¡¡mistakes¡¡made¡¡in¡¡the¡¡anatomy¡¡of¡¡the¡¡bones¡¡as¡¡described¡¡by¡¡Vesalius¡£¡¡He¡¡also¡¡added¡¡much¡¡to¡¡the¡¡science¡¡by¡¡giving¡¡correct¡¡accounts¡¡of¡¡the¡¡shape¡¡and¡¡cavities¡¡of¡¡the¡¡heart£»¡¡and¡¡made¡¡many¡¡other¡¡discoveries¡¡of¡¡minor¡¡importance¡£¡¡Fallopius¡¡£¨1523¡1562£©¡¡added¡¡considerably¡¡to¡¡the¡¡general¡¡knowledge¡¡of¡¡anatomy£»¡¡made¡¡several¡¡discoveries¡¡in¡¡the¡¡anatomy¡¡of¡¡the¡¡ear£»¡¡and¡¡also¡¡several¡¡organs¡¡in¡¡the¡¡abdominal¡¡cavity¡£¡¡At¡¡this¡¡time¡¡a¡¡most¡¡vitally¡¡important¡¡controversy¡¡was¡¡in¡¡progress¡¡as¡¡to¡¡whether¡¡or¡¡not¡¡the¡¡veins¡¡of¡¡the¡¡bodies¡¡were¡¡supplied¡¡with¡¡valves£»¡¡many¡¡anatomists¡¡being¡¡unable¡¡to¡¡find¡¡them¡£¡¡etienne¡¡had¡¡first¡¡described¡¡these¡¡structures£»¡¡and¡¡Vesalius¡¡had¡¡confirmed¡¡his¡¡observations¡£¡¡It¡¡would¡¡seem¡¡as¡¡if¡¡there¡¡could¡¡be¡¡no¡¡difficulty¡¡in¡¡settling¡¡the¡¡question¡¡as¡¡to¡¡the¡¡fact¡¡of¡¡such¡¡valves¡¡being¡¡present¡¡in¡¡the¡¡vessels£»¡¡for¡¡the¡¡demonstration¡¡is¡¡so¡¡simple¡¡that¡¡it¡¡is¡¡now¡¡made¡¡daily¡¡by¡¡medical¡¡students¡¡in¡¡all¡¡physiological¡¡laboratories¡¡and¡¡dissecting¡rooms¡£¡¡But¡¡many¡¡of¡¡the¡¡great¡¡anatomists¡¡of¡¡the¡¡sixteenth¡¡century¡¡were¡¡unable¡¡to¡¡make¡¡this¡¡demonstration£»¡¡even¡¡when¡¡it¡¡had¡¡been¡¡brought¡¡to¡¡their¡¡attention¡¡by¡¡such¡¡an¡¡authority¡¡as¡¡Vesalius¡£¡¡Fallopius£»¡¡writing¡¡to¡¡Vesalius¡¡on¡¡the¡¡subject¡¡in¡¡1562£»¡¡declared¡¡that¡¡he¡¡was¡¡unable¡¡to¡¡find¡¡such¡¡valves¡£¡¡Others£»¡¡however£»¡¡such¡¡as¡¡Eustachius¡¡and¡¡Fabricius¡¡£¨1537¡1619£©£»¡¡were¡¡more¡¡successful£»¡¡and¡¡found¡¡and¡¡described¡¡these¡¡structures¡£¡¡But¡¡the¡¡purpose¡¡served¡¡by¡¡these¡¡valves¡¡was¡¡entirely¡¡misinterpreted¡£¡¡That¡¡they¡¡act¡¡in¡¡preventing¡¡the¡¡backward¡¡flow¡¡of¡¡the¡¡blood¡¡in¡¡the¡¡veins¡¡on¡¡its¡¡way¡¡to¡¡the¡¡heart£»¡¡just¡¡as¡¡the¡¡valves¡¡of¡¡the¡¡heart¡¡itself¡¡prevent¡¡regurgitation£»¡¡has¡¡been¡¡known¡¡since¡¡the¡¡time¡¡of¡¡Harvey£»¡¡but¡¡the¡¡best¡¡interpretation¡¡that¡¡could¡¡be¡¡given¡¡at¡¡that¡¡time£»¡¡even¡¡by¡¡such¡¡a¡¡man¡¡as¡¡Fabricius£»¡¡was¡¡that¡¡they¡¡acted¡¡in¡¡retarding¡¡the¡¡flow¡¡of¡¡the¡¡blood¡¡as¡¡it¡¡comes¡¡from¡¡the¡¡heart£»¡¡and¡¡thus¡¡prevent¡¡its¡¡too¡¡rapid¡¡distribution¡¡throughout¡¡the¡¡body¡£¡¡The¡¡fact¡¡that¡¡the¡¡blood¡¡might¡¡have¡¡been¡¡going¡¡towards¡¡the¡¡heart£»¡¡instead¡¡of¡¡coming¡¡from¡¡it£»¡¡seems¡¡never¡¡to¡¡have¡¡been¡¡considered¡¡seriously¡¡until¡¡demonstrated¡¡so¡¡conclusively¡¡by¡¡Harvey¡£¡¡Of¡¡this¡¡important¡¡and¡¡remarkable¡¡controversy¡¡over¡¡the¡¡valves¡¡in¡¡veins£»¡¡Withington¡¡has¡¡this¡¡to¡¡say£º¡¡¡¨This¡¡is¡¡truly¡¡a¡¡marvellous¡¡story¡£¡¡A¡¡great¡¡Galenic¡¡anatomist¡¡is¡¡first¡¡to¡¡give¡¡a¡¡full¡¡and¡¡correct¡¡description¡¡of¡¡the¡¡valves¡¡and¡¡their¡¡function£»¡¡but¡¡fails¡¡to¡¡see¡¡that¡¡any¡¡modification¡¡of¡¡the¡¡old¡¡view¡¡as¡¡to¡¡the¡¡motion¡¡of¡¡the¡¡blood¡¡is¡¡required¡£¡¡Two¡¡able¡¡dissectors¡¡carefully¡¡test¡¡their¡¡action¡¡by¡¡experiment£»¡¡and¡¡come¡¡to¡¡a¡¡result¡£¡¡the¡¡exact¡¡reverse¡¡of¡¡the¡¡truth¡£¡¡Urged¡¡by¡¡them£»¡¡the¡¡two¡¡foremost¡¡anatomists¡¡of¡¡the¡¡age¡¡make¡¡a¡¡special¡¡search¡¡for¡¡valves¡¡and¡¡fail¡¡to¡¡find¡¡them¡£¡¡Finally£»¡¡passing¡¡over¡¡lesser¡¡peculiarities£»¡¡an¡¡aged¡¡and¡¡honorable¡¡professor£»¡¡who¡¡has¡¡lived¡¡through¡¡all¡¡this£»¡¡calmly¡¡asserts¡¡that¡¡no¡¡anatomist£»¡¡ancient¡¡or¡¡modern£»¡¡has¡¡ever¡¡mentioned¡¡valves¡¡in¡¡veins¡¡till¡¡he¡¡discovered¡¡them¡¡in¡¡1574£¡¡¨£§2£§¡¡Among¡¡the¡¡anatomists¡¡who¡¡probably¡¡discovered¡¡these¡¡valves¡¡was¡¡Michael¡¡Servetus¡¡£¨1511¡1553£©£»¡¡but¡¡if¡¡this¡¡is¡¡somewhat¡¡in¡¡doubt£»¡¡it¡¡is¡¡certain¡¡that¡¡he¡¡discovered¡¡and¡¡described¡¡the¡¡pulmonary¡¡circulation£»¡¡and¡¡had¡¡a¡¡very¡¡clear¡¡idea¡¡of¡¡the¡¡process¡¡of¡¡respiration¡¡as¡¡carried¡¡on¡¡in¡¡the¡¡lungs¡£¡¡The¡¡description¡¡was¡¡contained¡¡in¡¡a¡¡famous¡¡document¡¡sent¡¡to¡¡Calvin¡¡in¡¡1545a¡¡document¡¡which¡¡the¡¡reformer¡¡carefully¡¡kept¡¡for¡¡seven¡¡years¡¡in¡¡order¡¡that¡¡he¡¡might¡¡make¡¡use¡¡of¡¡some¡¡of¡¡the¡¡heretical¡¡statements¡¡it¡¡contained¡¡to¡¡accomplish¡¡his¡¡desire¡¡of¡¡bringing¡¡its¡¡writer¡¡to¡¡the¡¡stake¡£¡¡The¡¡awful¡¡fate¡¡of¡¡Servetus£»¡¡the¡¡interesting¡¡character¡¡of¡¡the¡¡man£»¡¡and¡¡the¡¡fact¡¡that¡¡he¡¡came¡¡so¡¡near¡¡to¡¡anticipating¡¡the¡¡discoveries¡¡of¡¡Harvey¡¡make¡¡him¡¡one¡¡of¡¡the¡¡most¡¡interesting¡¡figures¡¡in¡¡medical¡¡history¡£¡¡In¡¡this¡¡document¡¡which¡¡was¡¡sent¡¡to¡¡Calvin£»¡¡Servetus¡¡rejected¡¡the¡¡doctrine¡¡of¡¡natural£»¡¡vital£»¡¡and¡¡animal¡¡spirits£»¡¡as¡¡contained¡¡in¡¡the¡¡veins£»¡¡arteries£»¡¡and¡¡nerves¡¡respectively£»¡¡and¡¡made¡¡the¡¡all¡important¡¡statement¡¡that¡¡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THE¡¡COMING¡¡OF¡¡HARVEY¡¡The¡¡time¡¡was¡¡ripe¡¡for¡¡the¡¡culminating¡¡discovery¡¡of¡¡the¡¡circulation¡¡of¡¡the¡¡blood£»¡¡but¡¡as¡¡yet¡¡no¡¡one¡¡had¡¡determined¡¡the¡¡all¡important¡¡fact¡¡that¡¡there¡¡are¡¡two¡¡currents¡¡of¡¡blood¡¡in¡¡the¡¡body£»¡¡one¡¡going¡¡to¡¡the¡¡heart£»¡¡one¡¡coming¡¡from¡¡it¡£¡¡The¡¡valves¡¡in¡¡the¡¡veins¡¡would¡¡seem¡¡to¡¡show¡¡conclusively¡¡that¡¡the¡¡venous¡¡current¡¡did¡¡not¡¡come¡¡from¡¡the¡¡heart£»¡¡and¡¡surgeons¡¡must¡¡have¡¡observed¡¡thousands¡¡of¡¡times¡¡the¡¡every¡day¡¡phenomenon¡¡of¡¡congested¡¡veins¡¡at¡¡the¡¡distal¡¡extremity¡¡of¡¡a¡¡limb¡¡around¡¡which¡¡a¡¡ligature¡¡or¡¡constriction¡¡of¡¡any¡¡kind¡¡had¡¡been¡¡placed£»¡¡and¡¡the¡¡simultaneous¡¡depletion¡¡of¡¡the¡¡vessels¡¡at¡¡the¡¡proximal¡¡points¡¡above¡¡the¡¡ligature¡£¡¡But¡¡it¡¡should¡¡be¡¡remembered¡¡that¡¡inductive¡¡science¡¡was¡¡in¡¡its¡¡infancy¡£¡¡This¡¡was¡¡the¡¡sixteenth£»¡¡not¡¡the¡¡nineteenth¡¡century£»¡¡and¡¡few¡¡men¡¡had¡¡learned¡¡to¡¡put¡¡implicit¡¡confidence¡¡in¡¡their¡¡observations¡¡and¡¡convictions¡¡when¡¡opposed¡¡to¡¡existing¡¡doctrines¡£¡¡The¡¡time¡¡was¡¡at¡¡hand£»¡¡however£»¡¡when¡¡such¡¡a¡¡man¡¡was¡¡to¡¡make¡¡his¡¡appearance£»¡¡and£»¡¡as¡¡in¡¡the¡¡case¡¡of¡¡so¡¡many¡¡revolutionary¡¡doctrines¡¡in¡¡science£»¡¡this¡¡man¡¡was¡¡an¡¡Englishman¡£¡¡It¡¡remained¡¡for¡¡William¡¡Harvey¡¡£¨1578¡1657£©¡¡to¡¡solve¡¡the¡¡great¡¡mystery¡¡which¡¡had¡¡puzzled¡¡the¡¡me