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The¡¡headache¡¡and¡¡discharge¡¡continue¡¡for¡¡a¡¡year£»¡¡and¡¡the¡¡swelling¡¡continually¡¡increases¡¡through¡¡life£»¡¡although¡¡the¡¡symptoms¡¡gradually¡¡disappear£»¡¡the¡¡skin¡¡not¡¡becoming¡¡involved£»¡¡and¡¡no¡¡pain¡¡being¡¡present¡£¡¡It¡¡has¡¡been¡¡noticed¡¡in¡¡young¡¡chimpanzees¡£¡¡The¡¡illustration¡¡represents¡¡a¡¡man¡¡of¡¡forty¡¡who¡¡suffered¡¡from¡¡the¡¡disease¡¡since¡¡puberty¡£¡¡Pressure¡¡on¡¡the¡¡eyeball¡¡had¡¡started¡¡and¡¡the¡¡native¡¡said¡¡he¡¡expected¡¡that¡¡in¡¡two¡¡years¡¡he¡¡would¡¡lose¡¡his¡¡sight¡£¡¡Figure¡¡251¡¡shows¡¡an¡¡analogous¡¡condition£»¡¡called¡¡by¡¡Hutchinson¡¡symmetric¡¡osteomata¡¡of¡¡the¡¡nasal¡¡processes¡¡of¡¡the¡¡maxilla¡£¡¡His¡¡patient¡¡was¡¡a¡¡native¡¡of¡¡Great¡¡Britain¡£
Among¡¡neuromata£»¡¡multiple¡¡neurofibroma¡¡is¡¡of¡¡considerable¡¡interest£»¡¡chiefly¡¡for¡¡the¡¡extent¡¡of¡¡general¡¡involvement¡£¡¡According¡¡to¡¡Senn£»¡¡Heusinger¡¡records¡¡the¡¡case¡¡of¡¡a¡¡sailor¡¡of¡¡twenty¡three¡¡in¡¡whom¡¡all¡¡the¡¡nerves¡¡were¡¡affected¡¡by¡¡numerous¡¡nodular¡¡enlargements¡£¡¡Not¡¡a¡¡nerve¡¡in¡¡the¡¡entire¡¡body¡¡was¡¡found¡¡normal¡£¡¡The¡¡enlargement¡¡was¡¡caused¡¡by¡¡increase¡¡in¡¡the¡¡connective¡¡tissue£»¡¡the¡¡axis¡cylinders¡¡being¡¡normal¡£¡¡In¡¡this¡¡case¡¡there¡¡was¡¡neither¡¡pain¡¡nor¡¡tenderness¡£
Prudden¡¡reports¡¡the¡¡case¡¡of¡¡a¡¡girl¡¡of¡¡twenty¡five¡¡who£»¡¡during¡¡convalescence¡¡from¡¡variola£»¡¡became¡¡paraplegic£»¡¡and¡¡during¡¡this¡¡time¡¡multiple¡¡neuromata¡¡appeared¡£¡¡At¡¡the¡¡postmortem¡¡more¡¡than¡¡a¡¡thousand¡¡tumors¡¡were¡¡found¡¡affecting¡¡not¡¡only¡¡the¡¡peripheral¡¡branches¡¡and¡¡the¡¡sympathetic£»¡¡but¡¡also¡¡the¡¡cranial¡¡nerves¡¡and¡¡the¡¡pneumogastric¡£¡¡Under¡¡the¡¡microscope¡¡these¡¡tumors¡¡showed¡¡an¡¡increase¡¡in¡¡the¡¡interfascicular¡¡as¡¡well¡¡as¡¡perivascular¡¡fibers£»¡¡but¡¡the¡¡nerve¡fibers¡¡were¡¡not¡¡increased¡¡in¡¡size¡¡or¡¡number¡£¡¡Virchow¡¡collected¡¡30¡¡cases¡¡of¡¡multiple¡¡neurofibromata¡£¡¡In¡¡one¡¡case¡¡he¡¡found¡¡500£»¡¡in¡¡another¡¡from¡¡800¡¡to¡¡1000¡¡tumors¡£
Plexiform¡¡neuroma¡¡is¡¡always¡¡congenital£»¡¡and¡¡is¡¡found¡¡most¡¡frequently¡¡in¡¡the¡¡temporal¡¡region£»¡¡the¡¡neck£»¡¡and¡¡the¡¡sides¡¡of¡¡the¡¡face£»¡¡but¡¡almost¡¡any¡¡part¡¡of¡¡the¡¡body¡¡may¡¡be¡¡affected¡£¡¡Christot¡¡reports¡¡two¡¡cases¡¡in¡¡which¡¡the¡¡tumors¡¡were¡¡located¡¡upon¡¡the¡¡cheek¡¡and¡¡the¡¡neck¡£¡¡Czerny¡¡observed¡¡a¡¡case¡¡in¡¡which¡¡the¡¡tumor¡¡involved¡¡the¡¡lumbar¡¡plexus¡£¡¡Quoted¡¡by¡¡Senn£»¡¡Campbell¡¡de¡¡Morgan¡¡met¡¡with¡¡a¡¡plexiform¡¡neuroma¡¡of¡¡the¡¡musculo¡spiral¡¡nerve¡¡and¡¡its¡¡branches¡£¡¡The¡¡patient¡¡was¡¡a¡¡young¡¡lady£»¡¡and¡¡the¡¡tumor£»¡¡which¡¡was¡¡not¡¡painful£»¡¡had¡¡undergone¡¡myxomatous¡¡degeneration¡£
Neuroma¡¡of¡¡the¡¡vulva¡¡is¡¡a¡¡pathologic¡¡curiosity¡£¡¡Simpson¡¡reports¡¡a¡¡case¡¡in¡¡which¡¡the¡¡tumor¡¡was¡¡a¡¡painful¡¡nodule¡¡situated¡¡near¡¡the¡¡urinary¡¡meatus¡£¡¡Kennedy¡¡mentions¡¡an¡¡instance¡¡in¡¡which¡¡the¡¡tumor¡¡appeared¡¡as¡¡extremely¡¡tender¡¡tubercles¡£
Tietze¡¡describes¡¡a¡¡woman¡¡of¡¡twenty¡seven¡¡who¡¡exhibited¡¡a¡¡marked¡¡type¡¡of¡¡plexiform¡¡neurofibroma¡£¡¡The¡¡growth¡¡was¡¡simply¡¡excised¡¡and¡¡recovery¡¡was¡¡promptly¡¡effected¡£
Carcinomatous¡¡growths£»¡¡if¡¡left¡¡to¡¡themselves£»¡¡make¡¡formidable¡¡devastations¡¡of¡¡the¡¡parts¡¡which¡¡they¡¡affect¡£¡¡Warren¡¡pictures¡¡a¡¡case¡¡of¡¡noli¡me¡tangere£»¡¡a¡¡destructive¡¡type¡¡of¡¡epithelial¡¡carcinoma¡£¡¡The¡¡patient¡¡suffered¡¡no¡¡enlargement¡¡of¡¡the¡¡lymphatic¡¡glands¡£¡¡The¡¡same¡¡absence¡¡of¡¡glandular¡¡involvement¡¡was¡¡observed¡¡in¡¡another¡¡individual£»¡¡in¡¡whom¡¡there¡¡was¡¡extensive¡¡ulceration¡£¡¡The¡¡disease¡¡had¡¡in¡¡this¡¡case¡¡originated¡¡in¡¡the¡¡scar¡¡of¡¡a¡¡gunshot¡¡wound¡¡received¡¡during¡¡the¡¡Civil¡¡War£»¡¡and¡¡had¡¡destroyed¡¡the¡¡side¡¡of¡¡the¡¡nose£»¡¡the¡¡eye£»¡¡the¡¡ear£»¡¡the¡¡cheek£»¡¡including¡¡the¡¡corresponding¡¡half¡¡of¡¡the¡¡upper¡¡and¡¡lower¡¡lips¡£
Harlan¡¡reports¡¡a¡¡most¡¡extraordinary¡¡epithelioma¡¡of¡¡the¡¡orbit¡¡in¡¡a¡¡boy¡¡of¡¡about¡¡five¡¡years¡£¡¡It¡¡followed¡¡enucleation£»¡¡and¡¡attained¡¡the¡¡size¡¡depicted¡¡in¡¡a¡¡few¡¡months¡£
Sarcomata£»¡¡if¡¡allowed¡¡full¡¡progress£»¡¡may¡¡attain¡¡great¡¡size¡£¡¡Plate¡¡10¡¡shows¡¡an¡¡enormous¡¡sarcoma¡¡of¡¡the¡¡buttocks¡¡in¡¡an¡¡adult¡¡negro¡£¡¡Fascial¡¡sarcomata¡¡are¡¡often¡¡seen¡¡of¡¡immense¡¡size¡£¡¡Senn¡¡shows¡¡a¡¡tumor¡¡of¡¡this¡¡variety¡¡which¡¡was¡¡situated¡¡between¡¡the¡¡scapulae¡£
Schwimmer¡¡records¡¡a¡¡curious¡¡case¡¡of¡¡universal¡¡small¡¡sarcomata¡¡over¡¡the¡¡whole¡¡body¡¡of¡¡a¡¡teacher¡¡of¡¡the¡¡age¡¡of¡¡twenty¡one£»¡¡in¡¡the¡¡Hungarian¡¡lowlands¡£¡¡The¡¡author¡¡called¡¡the¡¡disease¡¡sarcomata¡¡pigmentosum¡¡diffusum¡¡multiplex¡£
The¡¡bones¡¡are¡¡a¡¡common¡¡seat¡¡of¡¡sarcomatous¡¡growths£»¡¡the¡¡tumor¡¡in¡¡this¡¡instance¡¡being¡¡called¡¡osteosarcoma¡£¡¡It¡¡may¡¡affect¡¡any¡¡bone£»¡¡but¡¡rarely¡¡involves¡¡an¡¡articulation£»¡¡at¡¡times¡¡it¡¡skips¡¡the¡¡joint¡¡and¡¡goes¡¡to¡¡the¡¡neighboring¡¡bone¡£
A¡¡case¡¡of¡¡nasal¡¡sarcoma¡¡is¡¡shown¡¡by¡¡Moore¡£¡¡The¡¡tumor¡¡was¡¡located¡¡in¡¡the¡¡nasal¡¡septum£»¡¡and¡¡caused¡¡a¡¡frightful¡¡deformity¡£¡¡In¡¡this¡¡case¡¡pain¡¡was¡¡absent£»¡¡the¡¡sense¡¡of¡¡smell¡¡was¡¡lost£»¡¡and¡¡the¡¡sight¡¡of¡¡the¡¡right¡¡eye¡¡impaired¡£¡¡Moore¡¡attempted¡¡to¡¡remove¡¡the¡¡tumor£»¡¡but¡¡in¡¡consequence¡¡of¡¡some¡¡interference¡¡of¡¡respiration¡¡the¡¡patient¡¡died¡¡on¡¡the¡¡table¡£
Tiffany¡¡reports¡¡several¡¡interesting¡¡instances¡¡of¡¡sarcoma£»¡¡one¡¡in¡¡a¡¡white¡¡female¡¡of¡¡nineteen¡¡following¡¡a¡¡contusion¡¡of¡¡tibia¡£¡¡The¡¡growth¡¡had¡¡all¡¡the¡¡clinical¡¡history¡¡of¡¡an¡¡osteosarcoma¡¡of¡¡the¡¡tibia£»¡¡and¡¡was¡¡amputated¡¡and¡¡photographed¡¡after¡¡removal¡£¡¡In¡¡another¡¡case£»¡¡in¡¡a¡¡white¡¡male¡¡of¡¡thirty£»¡¡the¡¡same¡¡author¡¡successfully¡¡performed¡¡a¡¡hip¡amputation¡¡for¡¡a¡¡large¡¡sarcoma¡¡of¡¡the¡¡left¡¡femur¡£¡¡The¡¡removed¡¡member¡¡was¡¡sent¡¡entire¡¡to¡¡the¡¡Army¡¡Medical¡¡Museum¡¡at¡¡Washington¡£
The¡¡fatality¡¡and¡¡incurability¡¡of¡¡malignant¡¡growths¡¡has¡¡done¡¡much¡¡to¡¡stimulate¡¡daring¡¡and¡¡marvelous¡¡operations¡¡in¡¡surgery¡£¡¡The¡¡utter¡¡hopelessness¡¡of¡¡the¡¡case¡¡justifies¡¡almost¡¡any¡¡means¡¡of¡¡relief£»¡¡and¡¡many¡¡of¡¡the¡¡visceral¡¡operations£»¡¡resections¡¡of¡¡functional¡¡organs£»¡¡and¡¡extraordinary¡¡amputations¡¡that¡¡were¡¡never¡¡dreamed¡¡of¡¡in¡¡the¡¡early¡¡history¡¡of¡¡medicine¡¡are¡¡to¡day¡¡not¡¡only¡¡feasible¡¡and¡¡justifiable£»¡¡but¡¡even¡¡peremptorily¡¡demanded¡£
Varicose¡¡veins¡¡sometimes¡¡become¡¡so¡¡enlarged¡¡and¡¡distorted¡¡as¡¡to¡¡simulate¡¡the¡¡appearance¡¡of¡¡one¡¡varicose¡¡tumor¡£¡¡Adams¡¡describes¡¡a¡¡curious¡¡case¡¡of¡¡congenital¡¡dilatation¡¡of¡¡the¡¡arteries¡¡and¡¡veins¡¡in¡¡the¡¡right¡¡lower¡¡limb£»¡¡accompanied¡¡by¡¡an¡¡anastomosis¡¡with¡¡the¡¡interior¡¡of¡¡the¡¡os¡¡calcis¡£¡¡The¡¡affected¡¡thigh¡¡exceeded¡¡the¡¡other¡¡in¡¡size¡¡by¡¡one¡third£»¡¡all¡¡the¡¡veins¡¡being¡¡immensely¡¡swelled¡¡and¡¡distorted¡£¡¡The¡¡arteries¡¡were¡¡also¡¡distorted¡¡and¡¡could¡¡be¡¡felt¡¡pulsating¡¡all¡¡over¡¡the¡¡limb¡£¡¡The¡¡patient¡¡died¡¡at¡¡thirty¡¡from¡¡rupture¡¡of¡¡the¡¡aneurysm¡£
Abbe¡¡shows¡¡a¡¡peculiar¡¡aneurysmal¡¡varix¡¡of¡¡the¡¡finger¡¡in¡¡a¡¡boy¡¡of¡¡nine¡£¡¡When¡¡a¡¡babe¡¡the¡¡patient¡¡had£»¡¡on¡¡the¡¡dorsum¡¡of¡¡the¡¡little¡¡finger£»¡¡a¡¡small¡¡nevus£»¡¡which¡¡was¡¡quiescent¡¡for¡¡many¡¡years¡£¡¡He¡¡received¡¡a¡¡deep¡¡cut¡¡at¡¡the¡¡base¡¡of¡¡the¡¡thumb£»¡¡and¡¡immediately¡¡after¡¡this¡¡accident¡¡the¡¡nevus¡¡began¡¡to¡¡enlarge¡¡rapidly¡£¡¡But¡¡for¡¡the¡¡local¡¡aneurysmal¡¡thrill¡¡at¡¡the¡¡point¡¡of¡¡the¡¡scar¡¡the¡¡condition¡¡would¡¡have¡¡been¡¡diagnosed¡¡as¡¡angioma£»¡¡but¡¡as¡¡a¡¡bruit¡¡could¡¡be¡¡heard¡¡over¡¡the¡¡entire¡¡mass¡¡it¡¡was¡¡called¡¡an¡¡aneurysmal¡¡varix£»¡¡because¡¡it¡¡was¡¡believed¡¡there¡¡was¡¡a¡¡connection¡¡between¡¡a¡¡rather¡¡large¡¡artery¡¡and¡¡a¡¡vein¡¡close¡¡to¡¡the¡¡mass¡£¡¡There¡¡is¡¡a¡¡curious¡¡case¡¡reported¡¡of¡¡cirsoid¡¡tumor¡¡of¡¡the¡¡ear¡¡of¡¡a¡¡boy¡¡of¡¡thirteen¡£¡¡Figure¡¡259¡¡shows¡¡the¡¡appearance¡¡before¡¡and¡¡after¡¡operation¡£
Jessop¡¡records¡¡a¡¡remarkable¡¡case¡¡of¡¡multiple¡¡aneurysm¡£¡¡This¡¡case¡¡was¡¡particularly¡¡interesting¡¡as¡¡it¡¡was¡¡accompanied¡¡by¡¡a¡¡postmortem¡¡examination¡£¡¡Pye¡Smith¡¡reports¡¡an¡¡extremely¡¡interesting¡¡case¡¡in¡¡which¡¡death¡¡occurred¡¡from¡¡traumatic¡¡aneurysm¡¡of¡¡an¡¡aberrant¡¡subclavian¡¡artery¡£¡¡The¡¡patient¡¡fell¡¡from¡¡a¡¡height¡¡of¡¡28¡¡feet£»¡¡lost¡¡consciousness¡¡for¡¡a¡¡few¡¡minutes£»¡¡but¡¡soon¡¡recovered¡¡it¡£¡¡There¡¡was¡¡no¡¡evidence¡¡of¡¡any¡¡fracture£»¡¡but¡¡the¡¡man¡¡suffered¡¡greatly¡¡from¡¡dyspnea£»¡¡pain¡¡between¡¡the¡¡shoulders£»¡¡and¡¡collapse¡£¡¡The¡¡breath¡sounds¡¡on¡¡auscultation¡¡and¡¡the¡¡difficulty¡¡in¡¡swallowing¡¡led¡¡to¡¡the¡¡belief¡¡that¡¡one¡¡of¡¡the¡¡bronchi¡¡was¡¡blocked¡¡by¡¡the¡¡pressure¡¡of¡¡a¡¡hematoma¡£¡¡Dyspnea¡¡continued¡¡to¡¡increase£»¡¡and¡¡eighteen¡¡days¡¡after¡¡admission¡¡the¡¡man¡¡was¡¡in¡¡great¡¡distress£»¡¡very¡¡little¡¡air¡¡entering¡¡the¡¡chest¡£¡¡He¡¡had¡¡no¡¡pulse¡¡at¡¡the¡¡right¡¡wrist£»¡¡and¡¡Pye¡Smith¡¡was¡¡unable¡¡to¡¡feel¡¡either¡¡the¡¡temporal¡¡or¡¡carotid¡¡beats¡¡on¡¡the¡¡right¡¡side£»¡¡although¡¡these¡¡vessels¡¡were¡¡felt¡¡pulsating¡¡on¡¡the¡¡left¡¡side¡£¡¡Laryngotomy¡¡was¡¡done¡¡with¡¡the¡¡hope¡¡of¡¡removing¡¡a¡¡foreign¡¡body£»¡¡but¡¡the¡¡man¡¡died¡¡on¡¡the¡¡tenth¡¡day¡£¡¡A¡¡postmortem¡¡examination¡¡disclosed¡¡the¡¡existence¡¡of¡¡an¡¡aberrant¡¡right¡¡subclavian¡¡artery¡¡in¡¡the¡¡posterior¡¡mediastinum£»¡¡and¡¡this¡¡was¡¡the¡¡seat¡¡of¡¡a¡¡traumatic¡¡aneurysm¡¡that¡¡had¡¡ruptured¡¡into¡¡the¡¡esophagus¡£
Relative¡¡to¡¡the¡¡size¡¡of¡¡an¡¡aneurysm£»¡¡Warren¡¡reported¡¡a¡¡case¡¡of¡¡the¡¡abdominal¡¡aorta¡¡which¡¡commenced¡¡at¡¡the¡¡origin¡¡of¡¡the¡¡celiac¡¡axis¡¡and¡¡passed¡¡on¡¡to¡¡the¡¡surfaces¡¡of¡¡the¡¡psoas¡¡and¡¡iliac¡¡muscles£»¡¡descending¡¡to¡¡the¡¡middle¡¡of¡¡the¡¡thigh¡¡The¡¡total¡¡length¡¡of¡¡the¡¡aneurysm¡¡was¡¡19¡¡inches£»¡¡and¡¡it¡¡measured¡¡18¡¡inches¡¡in¡¡circumference¡£
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Large¡¡Uterine¡¡Tumors¡£Before¡¡the¡¡meeting¡¡of¡¡the¡¡American¡¡Medical¡¡Association¡¡held¡¡in¡¡Washington£»¡¡D¡£C¡££»¡¡1891£»¡¡McIntyre¡¡a¡¡reported¡¡a¡¡case¡¡of¡¡great¡¡interest¡£¡¡The¡¡patient£»¡¡a¡¡woman¡¡of¡¡thirty¡eight£»¡¡five¡¡feet¡¡5¡¡1/2¡¡inches¡¡in¡¡height£»¡¡coarse£»¡¡with¡¡masculine¡¡features£»¡¡h