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The¡¡first¡¡accurate¡¡ideas¡¡in¡¡reference¡¡to¡¡elephantiasis¡¡arabum¡¡are¡¡given¡¡by¡¡Rhazes£»¡¡Haly¡Abas£»¡¡and¡¡Avicenna£»¡¡and¡¡it¡¡is¡¡possibly¡¡on¡¡this¡¡account¡¡that¡¡the¡¡disease¡¡received¡¡the¡¡name¡¡elephantiasis¡¡arabum¡£¡¡The¡¡disease¡¡was¡¡afterward¡¡noticed¡¡by¡¡Forestus£»¡¡Mercurialis£»¡¡Kaempfer£»¡¡Ludoff£»¡¡and¡¡others¡£¡¡In¡¡1719¡¡Prosper¡¡Alpinus¡¡wrote¡¡of¡¡it¡¡in¡¡Egypt£»¡¡and¡¡the¡¡medical¡¡officers¡¡of¡¡the¡¡French¡¡army¡¡that¡¡invaded¡¡Egypt¡¡became¡¡familiar¡¡with¡¡it£»¡¡since¡¡then¡¡the¡¡disease¡¡has¡¡been¡¡well¡¡known¡£
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Lymphedema£»¡¡or¡¡elephantiasis¡¡arabum£»¡¡is¡¡a¡¡condition¡¡in¡¡which£»¡¡in¡¡the¡¡substance¡¡of¡¡a¡¡limb¡¡or¡¡a¡¡part£»¡¡there¡¡is¡¡diffused¡¡dilatation¡¡of¡¡the¡¡lymphatics£»¡¡with¡¡lymphostasis¡£¡¡Such¡¡a¡¡condition¡¡results¡¡when¡¡there¡¡is¡¡obstruction¡¡of¡¡so¡¡large¡¡a¡¡number¡¡of¡¡the¡¡ducts¡¡converging¡¡to¡¡the¡¡root¡¡of¡¡the¡¡extremity¡¡or¡¡part¡¡that¡¡but¡¡little¡¡relief¡¡through¡¡collateral¡¡trunks¡¡is¡¡possible¡£¡¡The¡¡affected¡¡part¡¡becomes¡¡swollen¡¡and¡¡hardened£»¡¡and¡¡sometimes¡¡attains¡¡an¡¡enormous¡¡size¡£¡¡It¡¡is¡¡neither¡¡reducible¡¡by¡¡position¡¡nor¡¡pressure¡£¡¡There¡¡is¡¡a¡¡corresponding¡¡dilatation¡¡and¡¡multiplication¡¡of¡¡the¡¡blood¡vessels¡¡with¡¡the¡¡connective¡tissue¡¡hypertrophy¡£¡¡The¡¡muscles¡¡waste£»¡¡the¡¡skin¡¡becomes¡¡coarse¡¡and¡¡hypertrophied¡£¡¡The¡¡swollen¡¡limb¡¡presents¡¡immense¡¡lobulated¡¡masses£»¡¡heaped¡¡up¡¡at¡¡different¡¡parts£»¡¡separated¡¡from¡¡one¡¡another¡¡by¡¡deep¡¡sulci£»¡¡which¡¡are¡¡especially¡¡marked¡¡at¡¡the¡¡flexures¡¡of¡¡the¡¡joints¡£¡¡Although¡¡elephantiasis¡¡is¡¡met¡¡with¡¡in¡¡all¡¡climates£»¡¡it¡¡is¡¡more¡¡common¡¡in¡¡the¡¡tropics£»¡¡and¡¡its¡¡occurrence¡¡has¡¡been¡¡repeatedly¡¡demonstrated¡¡in¡¡these¡¡localities¡¡to¡¡be¡¡dependent¡¡on¡¡the¡¡presence¡¡in¡¡the¡¡lymphatics¡¡of¡¡the¡¡filaria¡¡sanguinis¡¡hominis¡£¡¡The¡¡accompanying¡¡illustration¡¡shows¡¡the¡¡condition¡¡of¡¡the¡¡limb¡¡of¡¡a¡¡girl¡¡of¡¡twenty¡one£»¡¡the¡¡subject¡¡of¡¡lymphedema£»¡¡five¡¡years¡¡after¡¡the¡¡inception¡¡of¡¡the¡¡disease¡£¡¡The¡¡changes¡¡in¡¡the¡¡limb¡¡were¡¡as¡¡yet¡¡moderate¡£¡¡The¡¡photograph¡¡from¡¡which¡¡the¡¡cut¡¡was¡¡made¡¡was¡¡taken¡¡in¡¡1875¡¡At¡¡the¡¡present¡¡time¡¡£¨seventeen¡¡years¡¡later£©¡¡the¡¡case¡¡presents¡¡the¡¡typical¡¡condition¡¡of¡¡the¡¡worst¡¡form¡¡of¡¡elephantiasis¡£¡¡Repeated¡¡attacks¡¡of¡¡lymphangitis¡¡have¡¡occurred¡¡during¡¡this¡¡period£»¡¡each¡¡producing¡¡an¡¡aggravation¡¡of¡¡the¡¡previous¡¡condition¡£¡¡The¡¡leg¡¡below¡¡the¡¡knee¡¡has¡¡become¡¡enormously¡¡deformed¡¡by¡¡the¡¡production¡¡of¡¡the¡¡elephantoid¡¡masses£»¡¡the¡¡outer¡¡side¡¡of¡¡the¡¡thigh¡¡remains¡¡healthy£»¡¡but¡¡the¡¡skin¡¡of¡¡the¡¡inner¡¡side¡¡has¡¡developed¡¡so¡¡as¡¡to¡¡form¡¡a¡¡very¡¡large¡¡and¡¡pendant¡¡lobulated¡¡mass¡£¡¡A¡¡similar¡¡condition¡¡has¡¡begun¡¡to¡¡develop¡¡in¡¡the¡¡other¡¡leg£»¡¡which¡¡is¡¡row¡¡about¡¡in¡¡the¡¡condition¡¡of¡¡the¡¡first£»¡¡as¡¡shown¡¡in¡¡the¡¡figure¡£¡¡Figure¡¡273¡¡represents¡¡this¡¡disease¡¡in¡¡its¡¡most¡¡aggravated¡¡form£»¡¡a¡¡condition¡¡rarely¡¡observed¡¡in¡¡this¡¡country¡£¡¡As¡¡an¡¡example¡¡of¡¡the¡¡change¡¡in¡¡the¡¡weight¡¡of¡¡a¡¡person¡¡after¡¡the¡¡inception¡¡of¡¡this¡¡disease£»¡¡we¡¡cite¡¡a¡¡case¡¡reported¡¡by¡¡Griffiths¡£¡¡The¡¡patient¡¡was¡¡a¡¡woman¡¡of¡¡fifty¡two¡¡who£»¡¡five¡¡years¡¡previous£»¡¡weighed¡¡148¡¡pounds¡£¡¡The¡¡elephantoid¡¡change¡¡was¡¡below¡¡the¡¡waist£»¡¡yet¡¡at¡¡the¡¡time¡¡of¡¡report¡¡the¡¡woman¡¡weighed¡¡387¡¡pounds¡£¡¡There¡¡was¡¡little¡¡thickening¡¡of¡¡the¡¡skin¡£¡¡The¡¡circumference¡¡of¡¡the¡¡calf¡¡was¡¡28¡¡inches£»¡¡of¡¡the¡¡thigh£»¡¡38¡¡inches£»¡¡and¡¡of¡¡the¡¡abdomen£»¡¡80¡¡inches£»¡¡while¡¡that¡¡of¡¡the¡¡arm¡¡was¡¡only¡¡15¡¡inches¡£
The¡¡condition¡¡commonly¡¡known¡¡as¡¡¡¨Barbadoes¡¡leg¡¨¡¡is¡¡a¡¡form¡¡of¡¡elephantiasis¡¡deriving¡¡its¡¡name¡¡from¡¡its¡¡relative¡¡frequency¡¡in¡¡Barbadoes¡£
Figure¡¡275¡¡represents¡¡a¡¡well¡known¡¡exhibitionist¡¡who£»¡¡from¡¡all¡¡appearances£»¡¡is¡¡suffering¡¡from¡¡an¡¡elephantoid¡¡hypertrophy¡¡of¡¡the¡¡lower¡¡extremities£»¡¡due¡¡to¡¡a¡¡lymphedema¡£¡¡Quite¡¡a¡¡number¡¡of¡¡similar¡¡exhibitionists¡¡have¡¡been¡¡shown¡¡in¡¡recent¡¡years£»¡¡the¡¡most¡¡celebrated¡¡of¡¡whom¡¡was¡¡Falmy¡¡Mills£»¡¡one¡¡of¡¡whose¡¡feet¡¡alone¡¡was¡¡extensively¡¡involved£»¡¡and¡¡was¡¡perhaps¡¡the¡¡largest¡¡foot¡¡ever¡¡seen¡£
Elephantiasis¡¡seldom¡¡attacks¡¡the¡¡upper¡¡extremities¡£¡¡Of¡¡the¡¡older¡¡cases¡¡Rayer¡¡reports¡¡four¡¡collected¡¡by¡¡Alard¡£¡¡In¡¡one¡¡case¡¡the¡¡hard¡¡and¡¡permanent¡¡swelling¡¡of¡¡the¡¡arm¡¡occurred¡¡after¡¡the¡¡application¡¡of¡¡a¡¡blister£»¡¡in¡¡another¡¡the¡¡arm¡¡increased¡¡so¡¡that¡¡it¡¡weighed¡¡more¡¡than¡¡200¡¡Genoese¡¡pounds£»¡¡40¡¡of¡¡which¡¡consisted¡¡of¡¡serum¡£¡¡The¡¡swellings¡¡of¡¡the¡¡arm¡¡and¡¡forearm¡¡resembled¡¡a¡¡distended¡¡bladder¡£¡¡The¡¡arteries£»¡¡veins£»¡¡and¡¡nerves¡¡had¡¡not¡¡undergone¡¡any¡¡alteration£»¡¡but¡¡the¡¡lymphatics¡¡were¡¡very¡¡much¡¡dilated¡¡and¡¡loaded¡¡with¡¡lymph¡£
The¡¡third¡¡case¡¡was¡¡from¡¡Fabricius¡¡Hildanus£»¡¡and¡¡the¡¡fourth¡¡from¡¡Hendy¡£¡¡Figure¡¡276¡¡represents¡¡a¡¡remarkable¡¡elephantoid¡¡change¡¡in¡¡the¡¡hand¡¡of¡¡an¡¡elderly¡¡German¡¡woman¡£¡¡Unfortunately¡¡there¡¡is¡¡no¡¡medical¡¡description¡¡of¡¡the¡¡case¡¡on¡¡record£»¡¡but¡¡the¡¡photograph¡¡is¡¡deemed¡¡worthy¡¡of¡¡reproduction¡£
Terry¡¡describes¡¡a¡¡French¡¡mulatto¡¡girl¡¡of¡¡eleven¡¡whose¡¡left¡¡hand¡¡was¡¡enormously¡¡increased¡¡in¡¡weight¡¡and¡¡consistency£»¡¡the¡¡chief¡¡enlargement¡¡being¡¡in¡¡the¡¡middle¡¡finger£»¡¡which¡¡was¡¡6¡¡1/2¡¡inches¡¡long£»¡¡and¡¡5¡¡1/2¡¡inches¡¡about¡¡the¡¡nail£»¡¡and¡¡8¡¡1/2¡¡around¡¡the¡¡base¡¡of¡¡the¡¡finger¡£¡¡The¡¡index¡¡finger¡¡was¡¡two¡¡inches¡¡thick¡¡and¡¡four¡¡inches¡¡long£»¡¡twisted¡¡and¡¡drawn£»¡¡while¡¡the¡¡other¡¡fingers¡¡were¡¡dwarfed¡£¡¡The¡¡elephantiasis¡¡in¡¡this¡¡case¡¡slowly¡¡and¡¡gradually¡¡increased¡¡in¡¡size¡¡until¡¡the¡¡hand¡¡weighed¡¡3¡¡1/2¡¡pounds¡£¡¡The¡¡skin¡¡of¡¡the¡¡affected¡¡finger£»¡¡contrary¡¡to¡¡the¡¡general¡¡appearance¡¡of¡¡a¡¡part¡¡affected¡¡with¡¡elephantiasis£»¡¡was¡¡of¡¡normal¡¡color£»¡¡smooth£»¡¡shiny£»¡¡showed¡¡no¡¡sensibility£»¡¡and¡¡the¡¡muscles¡¡had¡¡undergone¡¡fatty¡¡degeneration¡£¡¡It¡¡was¡¡successfully¡¡amputated¡¡in¡¡August£»¡¡1894¡£¡¡The¡¡accompanying¡¡illustration¡¡shows¡¡a¡¡dorsal¡¡view¡¡of¡¡the¡¡affected¡¡hand¡£
Magalhaes¡¡of¡¡Rio¡¡Janeiro¡¡reports¡¡a¡¡very¡¡interesting¡¡case¡¡of¡¡elephantiasis¡¡of¡¡the¡¡scalp£»¡¡representing¡¡dermatolysis£»¡¡in¡¡which¡¡the¡¡fold¡¡of¡¡hypertrophied¡¡skin¡¡fell¡¡over¡¡the¡¡face¡¡like¡¡the¡¡hide¡¡of¡¡an¡¡elephant£»¡¡somewhat¡¡similar¡¡in¡¡appearance¡¡to¡¡the¡¡¡¨elephant¡man¡£¡¨¡¡Figure¡¡279¡¡represents¡¡a¡¡somewhat¡¡similar¡¡hypertrophic¡¡condition¡¡of¡¡the¡¡scalp¡¡and¡¡face¡¡reported¡¡in¡¡the¡¡Ph